How is progeny genome synthesis carried out after retrovirus infection?

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Progeny genome synthesis after retrovirus infection primarily involves the process of reverse transcription, where the viral RNA genome is converted into DNA, which then integrates into the host cell's genome. This process is facilitated by the viral enzyme reverse transcriptase, which has both RNA-dependent DNA polymerase and DNA-dependent DNA polymerase activity.

In this context, the correct answer should focus on the role of viral reverse transcriptase. The synthesis of viral progeny genomes does not predominantly occur through host cell processes, nor does it involve host cell RNA polymerase directly. Instead, reverse transcriptase synthesizes DNA from the viral RNA template. After this initial reverse transcription, the newly formed viral DNA can integrate into the host genome, where it employs host cell machinery for further transcription and translation into new viral proteins and genomes.

Therefore, the synthesis of progeny genomes is primarily dependent on the viral reverse transcriptase's activity rather than a host-related process or another protein complex. Understanding this mechanism is crucial for comprehending the lifecycle of retroviruses and how they hijack host cellular processes for their propagation.

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